new paper from the group

10 June 2021
new paper from the group

Check out how faulty proteins are extracted across the membranes of cellular organelles to be degraded by the proteasome in the cytosol. Summarised in a hot-off-the-press review by Kvido Strisovsky and Marius Lemberg in Molecular Cell.

Hanka joins the group.

1 February 2021

Mgr. Hana Dvořáková has worked in parasitology at Charles University, and now joins our group at IOCB as a research assistant. Welcome!

Blanka leaves the group.

3 January 2021
Blanka Collis leaves the group after four great years as a postdoc. Blanka has done a great amount of work some of which has ended up in papers, and more is waiting to be put together. We all greatly enjoyed having you as a colleague and friend, but we understand it may be the time to move on. You will be a great asset to the Grant Office of IOCB. You will be sorely missed in the lab, but we are lucky you are not going that far and we can still meet you almost every day and have lunch together! :)

Best of luck!

Jan Skerle passes his PhD viva!

1 October 2020
Jan Skerle passes his PhD viva!
In a short coronavirus-free window, Jan Skerle passes his PhD viva at the Department of Biochemistry of Charles University. Congratulations, Dr. Skerle!

new paper from the lab

6 September 2020
new paper from the lab
Gandhi et al. Cell Chem Biol 2020

Our collaboration with the former Urban laboratory over the last few years has yielded this article in Cell Chemical Biology, which shows that pharmacological targetting of Plasmodium falciparum rhomboid proteases by ketoamides is feasible. Inhibition of PfROM4 blocks the entry of the parasite into the host cells and cures the culture, hence establishing Plasmodium rhomboids as new drug targets.

Marketa Barinkova graduates!

18 August 2020
Marketa Barinkova graduates!
Markéta Bařinková passes her bachelor's viva at the Department of molecular biology and genetics of Charles University with flying colours. Marketa's thesis was on membrane protein quality control and she has done a great job! Congratulations, Markéta and best of luck in your further studies!

new papers from the lab

18 May 2020
new papers from the lab
Cover art by Oliver Hoeller at

Two back to back papers in collaboration with Thierry Doan in Marseille and Chris Tang in Oxford, showing that bacterial rhomboid proteases are key for membrane protein quality control in bacteria, both as proteases and pseudoproteases, which is reminiscent of ERAD and Derlins in eukaryotes.

Began J, Cordier B, Brezinova J, Delisle J, Hexnerova R, Srb P, Rampirova P, Kozisek M, Baudet M, Coute Y et al (2020) Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease. EMBO J 39: e102935

Liu G, Beaton SE, Grieve AG, Evans R, Rogers M, Strisovsky K, Armstrong FA, Freeman M, Exley RM, Tang CM (2020) Bacterial rhomboid proteases mediate quality control of orphan membrane proteins. EMBO J 39: e102922

And an interesting News and Views piece summarising both papers and giving a broad persective written by Knopf and Lemberg:

Knopf JD, Lemberg MK (2020) Derlins with scissors: primordial ERAD in bacteria. EMBO J 39: e105012

It was a great pleasure to work with all the collaborators including Oliver Hoeller for the cover art!

Particular congratulations to all first authors!

Alma awarded the IOCB postdoc fellowship

9 April 2020
Alma was awarded the competitive IOCB postdoc fellowship. Congratulations!

new paper from the lab

13 March 2020

New paper from the lab on FRET and membrane protein dimerization in membranes comes online in the Biophysical Journal. Excellent collaboration with biophysicist Dr. Jana Humpolíčková of IOCB!

Jakub had his PhD viva!

27 February 2020
Jakub Began has passed his PhD viva at Charles University with flying colours! Congratulations, Dr. Began, and best of luck for your future!