Blog
Alma Estefania Martinez Fernandez laves our group to take a position in her beloved home country! We are incredibly sad to see Alma leave, but as all good things come to an end, here it is. Good luck, Alma! We have enjoyed working with you very much!!! Any time you pass through Prague, let us know! :)
A second leaving long-time member of the lab is Edita Polachova. Edita has finished her PhD (well, almost there) with her beautiful paper in J Med Chem freshly out. All the best, Edita, All the best, Edita, thank you for all you have done, and keep going until the finish line! :)
We are hiring! We are looking for PhD student and/or postdoc experienced in structural biology (xray/cryoEM) to join our dynamic international team striving to understand ADAM17 regulation in inflammatory and growth factor signalling. Funding provided. Email Kvido to find out more.
Our work on ketoamide inhibitors of the human mitochondrial rhomboid protease PARL has just come out in the Journal of Medicinal Chemistry. Congratulations to Edita, Kathrin, Stancho, Anežka! An enjoyable collaboration with the Lemberg lab at the University of Cologne and Thomas Langer lab at the MPI for Ageing in Cologne, Germany.
We show that potent inhibitors of human PARL activate the PINK1/Parkin pathway in cells, which is associated with the activation of mitophagy.
Watch this space!