New paper from the group
20 December 2022
Our work on ketoamide inhibitors of the human mitochondrial rhomboid protease PARL has just come out in the Journal of Medicinal Chemistry. Congratulations to Edita, Kathrin, Stancho, Anežka! An enjoyable collaboration with the Lemberg lab at the University of Cologne and Thomas Langer lab at the MPI for Ageing in Cologne, Germany.
We show that potent inhibitors of human PARL activate the PINK1/Parkin pathway in cells, which is associated with the activation of mitophagy.
Watch this space!